Could clazosentan, first approved in Japan, improve neurological prognosis after subarachnoid hemorrhage in combination with modified water-electrolyte management?

An aneurysmal subarachnoid hemorrhage (aSAH) is a devastating event associated with a high mortality and morbidity rate. Though numerous medications are used to prevent cerebral vasospasm and vasospasm-related cerebral infarction after aSAH, no effective pharmacological treatment has been establishe...

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Autors principals:	Eiji Shikata, Izumi Yamaguchi, Masaaki Korai, Takeshi Miyamoto, Tadashi Yamaguchi, Hiroshi Kagusa, Kenji Shimada, Yoshiteru Tada, Keiko T. Kitazato, Yasuhisa Kanematsu, Yasushi Takagi
Format:	Artigo
Idioma:	Inglês
Publicat:	KeAi Communications Co., Ltd. 2024-04-01
Col·lecció:	Brain Hemorrhages
Matèries:	Aneurysmal subarachnoid hemorrhage Cerebral vasospasm Endothelin Blood–brain barrier disruption Clazosentan Water-electrolyte management
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2589238X23000438
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