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Astrocytic SIRT1 ameliorates cognitive deficits after traumatic brain injury via autophagy-mediated MEGF10 phagocytosis

Abstract Traumatic brain injury (TBI) frequently causes cognitive dysfunction, with astrocytes playing a pivotal role in its pathogenesis. ​Specifically,​​ TBI triggers excessive astrocyte reactivity, ​leading to a phagocytic phenotype in astrocytes that contributes to abnormal synaptic phagocytosis...

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Principais autores: Qianxin Ji, Yan Zhang, Zhuo Zhang, Kun Cui, Liang Zhao, Xiaoyu Sun, Huiling Qu, Jia Song, Jianru Xiao, Xiaobin Zhang, Yu Lu, Jianan Xu, Dan Li
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-12-01
Serier:Journal of Neuroinflammation
Fag:
Astrocytic phagocytosis
Traumatic brain injury
Cognitive deficits
Online adgang:https://doi.org/10.1186/s12974-025-03633-x
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