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Tacrolimus—why pharmacokinetics matter in the clinic

The calcineurin inhibitor (CNI) Tacrolimus (Tac) is the most prescribed immunosuppressant drug after solid organ transplantation. After renal transplantation (RTx) approximately 95% of recipients are discharged with a Tac-based immunosuppressive regime. Despite the high immunosuppressive efficacy, i...

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Principais autores: Lino Henkel, Ulrich Jehn, Gerold Thölking, Stefan Reuter
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2023-08-01
סדרה:Frontiers in Transplantation
נושאים:
tacrolimus
tacrolimus pharmacokinetics
tacrolimus formulation
tacrolimus metabolism
kidney transplantation
renal transplantation
גישה מקוונת:https://www.frontiersin.org/articles/10.3389/frtra.2023.1160752/full
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