Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations
Down syndrome (DS) associates with impaired brain functions, but the underlying mechanism(s) are yet unclear. The “gene dosage” hypothesis predicts that in DS, overexpression of a single gene can impair multiple brain functions through a signal amplification effect due to impaired regulatory mechani...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2010-10-01
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| Serie: | Neurobiology of Disease |
| Soggetti: | |
| Accesso online: | http://www.sciencedirect.com/science/article/pii/S096999611000207X |
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