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Male-Dominant Spinal Microglia Contribute to Neuropathic Pain by Producing CC-Chemokine Ligand 4 Following Peripheral Nerve Injury

Recent studies have revealed marked sex differences in pathophysiological roles of spinal microglia in neuropathic pain, with microglia contributing to pain exacerbation exclusively in males. However, the characteristics of pain-enhancing microglia, which are more prominent in males, remain poorly u...

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Principais autores: Fumihiro Saika, Tetsuya Sato, Takeru Nakabayashi, Yohji Fukazawa, Shinjiro Hino, Kentaro Suzuki, Norikazu Kiguchi
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2025-03-01
coleção:Cells
Assuntos:
allodynia
CCL4
CCR5
female
inflammation
sex
Acesso em linha:https://www.mdpi.com/2073-4409/14/7/484
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