gtAI: an improved species-specific tRNA adaptation index using the genetic algorithm

The tRNA adaptation index (tAI) is a translation efficiency metric that considers weighted values (Sij values) for codon–tRNA wobble interaction efficiencies. The initial implementation of the tAI had significant flaws. For instance, generated Sij weights were optimized based on gene expression in S...

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Главные авторы:	Ali Mostafa Anwar, Saif M. Khodary, Eman Ali Ahmed, Aya Osama, Shahd Ezzeldin, Anthony Tanios, Sebaey Mahgoub, Sameh Magdeldin
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2023-07-01
Серии:	Frontiers in Molecular Biosciences
Предметы:	codon usage tRNA adaptation index molecular evolution translational selection codon usage analysis
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fmolb.2023.1218518/full
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