BCAT1 inhibits crotonate-related epigenetic modulation of metabolic genes in tumor-associated macrophages to counter immunosuppression

Abstract The heterogeneous and immunosuppressive tumor microenvironment (TME) in hepatocellular carcinoma (HCC) contributes to poor immunotherapy responses. Tumor-associated macrophages (TAM) are central to the immunosuppressive TME, but how metabolic programs regulate TAM pro-tumorigenic functions...

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Үндсэн зохиолчид:	Weizhi Zhang, Shuhang Liang, Sitao Han, Qingrui Zha, Linmao Sun, Shengwei Tao, Yunguang Zhang, Junhui Chu, Qi Chu, Ning Zhang, Kun Ma, Yufeng Liu, Tianming Cui, Xuetian Gu, Cheng Cheng, Xinyu Guo, Yumin Fu, Changjian Xing, Jiawei Duan, Yan Long, Dongdong Yang, Jiabei Wang, Lianxin Liu
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Portfolio 2026-05-01
Цуврал:	Nature Communications
Онлайн хандалт:	https://doi.org/10.1038/s41467-026-72814-w
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!