Reduced HGF/MET Signaling May Contribute to the Synaptic Pathology in an Alzheimer's Disease Mouse Model

Alzheimer's disease (AD) is a neurodegenerative disorder strongly associates with aging. While amyloid plagues and neurofibrillary tangles are pathological hallmarks of AD, recent evidence suggests synaptic dysfunction and physical loss may be the key mechanisms that determine the clinical syndrome...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Jing Wei, Xiaokuang Ma, Antoine Nehme, Yuehua Cui, Le Zhang, Shenfeng Qiu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2022-07-01
Schriftenreihe:	Frontiers in Aging Neuroscience
Schlagworte:	Alzheimer's disease MET receptor tyrosine kinase hepatocyte growth factor synaptic plasticity regeneration
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fnagi.2022.954266/full
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