Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of ATRIP-Seckel syndrome

Seckel syndrome is a type of microcephalic primordial dwarfism (MPD) that is characterized by growth retardation and neurodevelopmental defects, including reports of retinopathy. Mutations in key mediators of the replication stress response, the mutually dependent partners ATR and ATRIP, are among t...

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Autores principales:	Gabriel E. Matos-Rodrigues, Pedro B. Tan, Maurício Rocha-Martins, Clara F. Charlier, Anielle L. Gomes, Felipe Cabral-Miranda, Paulius Grigaravicius, Thomas G. Hofmann, Pierre-Olivier Frappart, Rodrigo A. P. Martins
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	The Company of Biologists 2020-10-01
Colección:	Disease Models & Mechanisms
Materias:	apoptosis dna damage response neurodevelopment neurodegeneration visual system development photoreceptor
Acceso en línea:	http://dmm.biologists.org/content/13/10/dmm045807
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