Dysregulation in IFN-γ signaling and response: the barricade to tumor immunotherapy

Interferon-gamma (IFN-γ) has been identified as a crucial factor in determining the responsiveness to immunotherapy. Produced primarily by natural killer (NK) and T cells, IFN-γ promotes activation, maturation, proliferation, cytokine expression, and effector function in immune cells, while simultan...

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Bibliografski detalji

Glavni autori:	Jiashu Han, Mengwei Wu, Ziwen Liu
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2023-05-01
Serija:	Frontiers in Immunology
Teme:	interferon immunotherapy immunoresistance ISG (interferon stimulated genes) IFNGR JAK - STAT signaling pathway
Online pristup:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1190333/full
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