Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific heterozygous mutation in CHMP2B

Frontotemporal dementia (FTD) is an early onset neurodegenerative disease. Mutations in several genes cause familial FTD and one of them is charged multivesicular body protein 2B (CHMP2B) on chromosome 3 (FTD3), a component of the endosomal sorting complex required for transport III (ESCRT-III). We...

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Huvudupphov:	Yu Zhang, Benjamin Schmid, Troels T. Nielsen, Jørgen E. Nielsen, Christian Clausen, Poul Hyttel, Bjørn Holst, Kristine K. Freude
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Elsevier 2016-07-01
Serie:	Stem Cell Research
Länkar:	http://www.sciencedirect.com/science/article/pii/S1873506116300678
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