Targeted Amino Acid Substitutions Impair Streptolysin O Toxicity and Group A <italic toggle="yes">Streptococcus</italic> Virulence
ABSTRACT Streptolysin O is a potent pore-forming toxin produced by group A Streptococcus. The aims of the present study were to dissect the relative contributions of different structural domains of the protein to hemolytic activity, to obtain a detoxified form of streptolysin O amenable to human vac...
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| Principais autores: | , , , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2013-03-01
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| coleção: | mBio |
| Acesso em linha: | https://journals.asm.org/doi/10.1128/mBio.00387-12 |
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