DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling

Summary: CDC7-DBF4 kinase (DDK) initiates DNA replication in eukaryotes by activating the replicative MCM helicase. DDK has diverse and apparently conflicting roles in the replication checkpoint response in various organisms, but the underlying mechanisms are far from settled. We show that human DDK...

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Podrobná bibliografie

Hlavní autoři:	Nanda Kumar Sasi, Flavie Coquel, Yea-Lih Lin, Jeffrey P MacKeigan, Philippe Pasero, Michael Weinreich
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2018-10-01
Edice:	Neoplasia: An International Journal for Oncology Research
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S1476558618302331
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