A regulatory role for repeated decoy transcription factor binding sites in target gene expression

Abstract Tandem repeats of DNA that contain transcription factor (TF) binding sites could serve as decoys, competitively binding to TFs and affecting target gene expression. Using a synthetic system in budding yeast, we demonstrate that repeated decoy sites inhibit gene expression by sequestering a...

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Hlavní autoři:	Tek‐Hyung Lee, Narendra Maheshri
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer Nature 2012-03-01
Edice:	Molecular Systems Biology
Témata:	bimodality tandem repeats transcription factor decoys transcriptional regulation
On-line přístup:	https://doi.org/10.1038/msb.2012.7
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