Complete Neutralization of Tetanus Neurotoxin by Alpaca-Derived Trivalent Nanobodies Aimed at Veterinary Medical Applications

Tetanus is a zoonotic disease posing significant threats to both humans and animals, particularly horses, sheep, and ruminants. Current antitoxin therapies rely on animal-derived immunoglobulins, presenting challenges including animal welfare concerns, pathogen contamination risks, and manufacturing...

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Autors principals:	Chiyomi Sakamoto, Chie Shitada, Norihiko Kiyose, Nobuo Miyazaki, Sena Kamesawa, Hiroshi Morioka, Kazunori Morokuma, Kazuhiko Tomokiyo, Motohide Takahashi
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2026-01-01
Col·lecció:	Veterinary Sciences
Matèries:	tetanus neurotoxin VHH VHH trimer neutralizing activity alpaca neutralization test
Accés en línia:	https://www.mdpi.com/2306-7381/13/1/98
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