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Disruption of hematopoiesis attenuates the osteogenic differentiation capacity of bone marrow stromal cells

Abstract Background The homeostasis of mesenchymal stem cells (MSCs) is modulated by both their own intracellular molecules and extracellular milieu signals. Hematopoiesis in the bone marrow is maintained by niche cells, including MSCs, and it is indispensable for life. The role of MSCs in maintaini...

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Principais autores: Changzhen Wang, Hongmei Ning, Jiao Gao, Teng Xue, Ming Zhao, Xiaoxia Jiang, Xiaoming Zhu, Ximin Guo, Hong Li, Xiaoyan Wang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2022-01-01
Serier:Stem Cell Research & Therapy
Fag:
Mesenchymal stem cells
Hematopoietic cells
Niche
Differentiation
Online adgang:https://doi.org/10.1186/s13287-022-02708-3
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