Conserved shifts in sperm small non-coding RNA profiles during mouse and human aging

Abstract Sperm aging impacts male fertility and offspring health, highlighting the need for reliable aging biomarkers to guide reproductive decisions. However, the molecular determinants of sperm fitness during aging remain ill-defined. Here, we profiled sperm small non-coding RNAs (sncRNAs) using P...

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Detalhes bibliográficos

Principais autores:	Junchao Shi, Xudong Zhang, Chen Cai, Shichao Liu, Jiancheng Yu, Emma R James, Lihua Liu, Benjamin R Emery, Megan R McMurray Bires, Elizabeth Torres-Arce, Hukam C Rawal, Joemy Ramsay, Jason Kunisaki, Changcheng Zhou, David S Milstone, Mary Elizabeth Patti, Xiaoxu Yang, Tim G Jenkins, Aaron Quinlan, Bradley R Cairns, Paul Schimmel, James M Hotaling, Kenneth I Aston, Tong Zhou, Qi Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2026-01-01
coleção:	The EMBO Journal
Assuntos:	Sperm Epigenetics Aging Clock Sperm RNA Code Paternal Age Effect Epigenetic Inheritance
Acesso em linha:	https://doi.org/10.1038/s44318-025-00687-8
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