T-cell responses against CD19-targeted CAR T cells varnimcabtagene autoleucel (ARI-0001): implications for immune response and therapy outcomes

Patients with B-cell malignancies receiving CD19-targeted chimeric antigen receptor (CAR) T-cell therapy may experience treatment failure due to various mechanisms. One significant factor is the host’s immune response against the CAR-T product, mainly triggered by the immunogenicity of non-human seq...

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Principais autores:	Manel Juan, Alvaro Urbano-Ispizua, Eddie James, William W Kwok, Susana Rives, Valentín Ortiz-Maldonado, Anna Alonso-Saladrigues, Julio Delgado, Europa Azucena González-Navarro, Ariadna Bartoló-Ibars, Andrea Aran, Alexandra M Johansson, Nela Klein-González
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMJ Publishing Group 2025-09-01
coleção:	Journal for ImmunoTherapy of Cancer
Acesso em linha:	https://jitc.bmj.com/content/13/9/e010792.full
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