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Early Intervention and Lifelong Treatment with GLP1 Receptor Agonist Liraglutide in a Wolfram Syndrome Rat Model with an Emphasis on Visual Neurodegeneration, Sensorineural Hearing Loss and Diabetic Phenotype

Wolfram syndrome (WS), also known as a DIDMOAD (diabetes insipidus, early-onset diabetes mellitus, optic nerve atrophy and deafness) is a rare autosomal disorder caused by mutations in the Wolframin1 (<i>WFS1</i>) gene. Previous studies have revealed that glucagon-like peptide-1 receptor agonist (GL...

Cur síos iomlán

Sábháilte in:
Príomhchruthaitheoirí: Toomas Jagomäe, Kadri Seppa, Riin Reimets, Marko Pastak, Mihkel Plaas, Miriam A. Hickey, Kaia Grete Kukker, Lieve Moons, Lies De Groef, Eero Vasar, Allen Kaasik, Anton Terasmaa, Mario Plaas
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: MDPI AG 2021-11-01
Sraith:Cells
Ábhair:
wolfram syndrome
Wfs1
GLP1 receptor agonist
liraglutide
rat model
neurodegeneration
Rochtain ar líne:https://www.mdpi.com/2073-4409/10/11/3193
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