The p53 tumor suppressor is stabilized by inhibitor of growth 1 (ING1) by blocking polyubiquitination.

The INhibitor of Growth tumor suppressors (ING1-ING5) affect aging, apoptosis, DNA repair and tumorigenesis. Plant homeodomains (PHD) of ING proteins bind histones in a methylation-sensitive manner to regulate chromatin structure. ING1 and ING2 contain a polybasic region (PBR) adjacent to their PHDs...

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Autors principals:	Subhash Thalappilly, Xiaolan Feng, Svitlana Pastyryeva, Keiko Suzuki, Daniel Muruve, Daniel Larocque, Stephane Richard, Matthias Truss, Andreas von Deimling, Karl Riabowol, Gesche Tallen
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2011-01-01
Col·lecció:	PLoS ONE
Accés en línia:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021065&type=printable
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