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The Type I Interferon Pathway Is Upregulated in the Cutaneous Lesions and Blood of Multibacillary Leprosy Patients With Erythema Nodosum Leprosum

In leprosy patients, acute inflammatory episodes, known as erythema nodosum leprosum (ENL), are responsible for high morbidity and tissue damage that occur during the course of Mycobacterium leprae infection. In a previous study, we showed evidence implicating DNA-sensing via TLR9 as an important in...

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Tallennettuna:
Päätekijät: Thabatta Leal Silveira Andrezo Rosa, Mayara Abud Mendes, Natasha Ribeiro Cardoso Linhares, Thais Fernanda Rodrigues, André Alves Dias, Thyago Leal-Calvo, Mariana Gandini, Helen Ferreira, Fabrício da Mota Ramalho Costa, Anna Maria Sales, Thaís Porto Amadeu, Veronica Schmitz, Roberta Olmo Pinheiro, Luciana Silva Rodrigues, Milton Ozório Moraes, Maria Cristina Vidal Pessolani
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2022-06-01
Sarja:Frontiers in Medicine
Aiheet:
immunopathogenesis
leprosy reaction
type I interferons
plasmacytoid dendritic cells
erythema nodosum leprosum
Linkit:https://www.frontiersin.org/articles/10.3389/fmed.2022.899998/full
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