The efficacy and safety of PD-1/PD-L1 inhibitors in combination with chemotherapy as a first-line treatment for unresectable, locally advanced, HER2-negative gastric or gastroesophageal junction cancer: a meta-analysis of randomized controlled trials

BackgroundImmune checkpoint inhibitors (ICIs) plus fluorouracil-based chemotherapy (Chemo) have been approved as an initial treatment strategy for metastatic or recurrent human epidermal growth factor receptor 2 (HER2)-negative gastric cancer (GC) or gastroesophageal junction cancer (GEJC). However,...

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Príomhchruthaitheoirí:	Wenji Pu, Shasha Li, Jinliang Zhang, Jijie Huang, Jishi Li, Yong Jiang, Zhiyuan Xu, Fan Yi, Yuling Lan, Qin Xiao, Wenqi Chen, Jing Jin
Formáid:	Artigo
Teanga:	Inglês
Foilsithe / Cruthaithe:	Frontiers Media S.A. 2025-03-01
Sraith:	Frontiers in Immunology
Ábhair:	advanced gastroesophageal cancer immune check points PD-1/PD-L1 inhibitors chemotherapy gastroesophageal adenocarcinoma gastric adenocarcinoma
Rochtain ar líne:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1566939/full
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