Novel mechanisms in alcohol neurodevelopmental disorders via BRCA1 depletion and BRCA1-dependent NADPH oxidase regulation

The breast cancer 1 protein (BRCA1) facilitates DNA repair, preventing embryolethality and protecting the fetus from reactive oxygen species (ROS)-induced developmental disorders mediated by oxidatively damaged DNA. Alcohol (ethanol, EtOH) exposure during pregnancy causes fetal alcohol spectrum diso...

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Detalhes bibliográficos

Principais autores:	Danielle M. Drake, Peter G. Wells
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-12-01
coleção:	Redox Biology
Assuntos:	Breast cancer 1 susceptibility gene (Brca1) Catalase Fear conditioning Neurodevelopmental disorders NADPH oxidase (NOX) Proteasomal activity
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2213231721003086
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