INFLUENCE OF THE CYP3A4 ISOENZYME METABOLIC ACTIVITY AND CYP2C19 GENE POLYMORPHISMS ON CLOPIDOGREL ANTIPLATELET EFFECT IN PATIENTS WITH ACUTE CORONARY SYNDROME UNDERGOING PERCUTANEOUS CORONARY INTERVENTION

<p><strong>Aim.</strong> Carriership of CYP2C19*2 allelic variant and reduced CYP3A4 activity can affect the formation of clopidogrel’s active metabolite and, respectively, its antiplatelet effect. We sought to determine the impact of CYP3A4 isoenzyme activity and CYP2C19 polymorphisms on platelet a...

Descrizione completa

Dettagli Bibliografici

Autori principali:	K. B. Mirzaev, R. E. Kazakov, V. V. Smirnov, D. A. Andreev, D. A. Sychev
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Столичная издательская компания 2015-09-01
Serie:	Рациональная фармакотерапия в кардиологии
Soggetti:	CYP2C19*2 острый коронарный синдром CYP3A4 фармакогенетика клопидогрел блокаторы P2Y12-рецепторов
Accesso online:	http://www.rpcardio.ru/jour/article/view/125
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!