S100a4 upregulation in Pik3caH1047R;Trp53R270H;MMTV-Cre-driven mammary tumors promotes metastasis

Abstract Background PIK3CA mutations are frequent in human breast cancer. Pik3caH1047R mutant expression in mouse mammary gland promotes tumorigenesis. TP53 mutations co-occur with PIK3CA mutations in human breast cancers. We previously generated a conditionally activatable Pik3caH1047R;MMTV-Cre mou...

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Autors principals:	Wenlin Yuan, Leonard D. Goldstein, Steffen Durinck, Ying-Jiun Chen, Thong T. Nguyen, Noelyn M. Kljavin, Ethan S. Sokol, Eric W. Stawiski, Benjamin Haley, James Ziai, Zora Modrusan, Somasekar Seshagiri
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2019-12-01
Col·lecció:	Breast Cancer Research
Matèries:	Pik3caH1047R Trp53R270H S100a4 Mammary tumors Breast cancer Metastasis
Accés en línia:	https://doi.org/10.1186/s13058-019-1238-5
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