Massively parallel sequencing of mitochondrial genome in primary open angle glaucoma identifies somatically acquired mitochondrial mutations in ocular tissue

Abstract Glaucoma is a sight threatening neurodegenerative condition of the optic nerve head associated with ageing and marked by the loss of retinal ganglion cells. Mitochondrial dysfunction plays a crucial role in the pathogenesis of neurodegeneration in the most prevalent type of glaucoma: primar...

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Prif Awduron:	Neeru Amrita Vallabh, Brian Lane, David Simpson, Marc Fuchs, Anshoo Choudhary, David Criddle, Robert Cheeseman, Colin Willoughby
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Nature Portfolio 2024-11-01
Cyfres:	Scientific Reports
Pynciau:	Tenon’s fibroblasts Glaucoma Mitochondrial genome Somatic mutations Massively parallel sequencing Mitochondrial DNA
Mynediad Ar-lein:	https://doi.org/10.1038/s41598-024-72684-6
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