Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2

The mitochondrial calcium uniporter is a Ca2+-gated ion channel complex that controls mitochondrial Ca2+ entry and regulates cell metabolism. MCU and EMRE form the channel while Ca2+-dependent regulation is conferred by MICU1 and MICU2 through an enigmatic process. We present a cryo-EM structure of...

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Autors principals:	Chongyuan Wang, Agata Jacewicz, Bryce D Delgado, Rozbeh Baradaran, Stephen Barstow Long
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2020-07-01
Col·lecció:	eLife
Matèries:	tribolium castaneum ion channel calcium channel toxin gating membrane structure
Accés en línia:	https://elifesciences.org/articles/59991
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