Is the antidepressant efficacy of ketamine and esketamine mediated via opioid mechanisms?

Abstract Background Ketamine and esketamine produce rapid and sustained antidepressant effects in persons with treatment-resistant depression (TRD). Although it is posited that these effects are largely attributed to N-methyl-D-aspartate receptor antagonism, the potential involvement of the opioid...

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Autors principals:	Andy Lu, Heidi Xu, Gia Han Le, Christine E. Dri, Sabrina Wong, Roger Ho, Bing Cao, Heidi Ka Ying Lo, Taeho Greg Rhee, Liyang Yin, Hernan F. Guillen-Burgos, Roger S. McIntyre
Format:	Artigo
Idioma:	Inglês
Publicat:	Cambridge University Press 2026-01-01
Col·lecció:	European Psychiatry
Matèries:	ketamine esketamine receptors opioid depressive disorder treatment-resistant major
Accés en línia:	https://www.cambridge.org/core/product/identifier/S0924933826101576/type/journal_article
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