Effect of hepatic NPC1L1 on cholesterol gallstone disease and its mechanism

Cholesterol gallstone disease (CGD) is associated with bile cholesterol supersaturation. The Niemann-Pick C1-like 1 (NPC1L1), the inhibitory target of ezetimibe (EZE), is a critical sterol transporter of cholesterol absorption. Intestinal NPC1L1 facilitates the absorption of cholesterol, whereas hep...

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Autors principals:	Pingfan Mo, Hongtan Chen, Xin Jiang, Fengling Hu, Fenming Zhang, Guodong Shan, Wenguo Chen, Sha Li, Guoqiang Xu
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2023-05-01
Col·lecció:	Heliyon
Matèries:	Cholesterol gallstone disease NPC1L1 Hepatic Ezetimibe
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S240584402302964X
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