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The Effects of Hypoxia on the Immune–Metabolic Interplay in Liver Cancer

M2-like macrophages promote tumor growth and cancer immune evasion. This study used an in vitro model to investigate how hypoxia and tumor metabolism affect macrophage polarization. Liver cancer cells (HepG2 and VX2) and macrophages (THP1) were cultured under hypoxic (0.1% O<sub>2</sub>) and normoxi...

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Autori principali: Yubei He, Han Xu, Yu Liu, Stefan Kempa, Carolina Vechiatto, Robin Schmidt, Emine Yaren Yilmaz, Luisa Heidemann, Jörg Schnorr, Susanne Metzkow, Eyk Schellenberger, Akvile Häckel, Andreas Patzak, Dominik N. Müller, Lynn Jeanette Savic
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2024-08-01
Serie:Biomolecules
Soggetti:
hepatocellular carcinoma (HCC)
hypoxia
M2-like polarization
GC-MS-based metabolic profiling
2-amino-butanoic acid (2A-BA)
Accesso online:https://www.mdpi.com/2218-273X/14/8/1024
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