A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response.

CD8 T cells provide limited protection against Mycobacterium tuberculosis (Mtb) infection in the mouse model. As Mtb causes chronic infection in mice and humans, we hypothesize that Mtb impairs T cell responses as an immune evasion strategy. TB10.4 is an immunodominant antigen in people, nonhuman pr...

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主要な著者:	Rujapak Sutiwisesak, Nathan D Hicks, Shayla Boyce, Kenan C Murphy, Kadamba Papavinasasundaram, Stephen M Carpenter, Julie Boucau, Neelambari Joshi, Sylvie Le Gall, Sarah M Fortune, Christopher M Sassetti, Samuel M Behar
フォーマット:	Artigo
言語:	Inglês
出版事項:	Public Library of Science (PLoS) 2020-10-01
シリーズ:	PLoS Pathogens
オンライン･アクセス:	https://doi.org/10.1371/journal.ppat.1009000
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