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α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons

Abstract Neuronal inclusions composed of α-synuclein (α-syn) characterize Parkinson’s Disease (PD) and Dementia with Lewy bodies (DLB). Cognitive dysfunction defines DLB, and up to 80% of PD patients develop dementia. α-Syn inclusions are abundant in the hippocampus, yet functional consequences are...

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Principais autores: Jessica M. Froula, Benjamin W. Henderson, Jose Carlos Gonzalez, Jada H. Vaden, John W. Mclean, Yumei Wu, Gokulakrishna Banumurthy, Linda Overstreet-Wadiche, Jeremy H. Herskowitz, Laura A. Volpicelli-Daley
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-05-01
coleção:Acta Neuropathologica Communications
Assuntos:
α-Synuclein
Lewy body
Lewy neurite
Dendritic spines
Fibril
Parkinson’s disease
Acesso em linha:http://link.springer.com/article/10.1186/s40478-018-0537-x
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