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Facile synthesis of sulfonamide libraries using a solid-polymer-supported HOBt scaffold

Using solid-phase synthetic methods, silica-bound 1-hydroxybenzotriazole (Si-HOBt) was prepared by coupling 3-aminopropyl silica gel with 1-hydroxybenzotriazole-6-carboxylic acid (HOBt-COOH). The Si-HOBt was activated by the reaction of Si-HOBT with 3,4-dihydroxy-9,10-dioxo-anthracenesulfonyl chlori...

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Principais autores: Jules Seh Noel Guei, Aristotle Kalivretenos, William R. LaCourse
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-01-01
Serier:Results in Chemistry
Fag:
Solid-Phase Synthesis
HOBt
Sulfonamides Library
Drug libraries
HPLC-UV
Combinatory Chemistry
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211715624000547
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