Generating universal anti-CD19 CAR T cells with a defined memory phenotype by CRISPR/Cas9 editing and safety evaluation of the transcriptome

IntroductionChimeric antigen receptor-expressing T cells (CAR T cells) have revolutionized cancer treatment, particularly in B cell malignancies. However, the use of autologous T cells for CAR T therapy presents several limitations, including high costs, variable efficacy, and adverse effects linked...

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Autores principales:	Kristina Pavlovic, MDolores Carmona-Luque, Giulia I. Corsi, Noelia Maldonado-Pérez, Francisco J. Molina-Estevez, Esther Peralbo-Santaella, Marina Cortijo-Gutiérrez, Pedro Justicia-Lirio, María Tristán-Manzano, Víctor Ronco-Díaz, Antonio Ballesteros-Ribelles, Alejandro Millán-López, Paula Heredia-Velázquez, Carla Fuster-García, Toni Cathomen, Stefan E. Seemann, Jan Gorodkin, Francisco Martin, Concha Herrera, Karim Benabdellah
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2024-05-01
Colección:	Frontiers in Immunology
Materias:	anti CD 19 CAR-T cells CRISPR/Cas9 allogeneic CAR-T cells memory CAR-T cells CRISPRroots
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1401683/full
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