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Mechanism of motoneuronal and pyramidal cell death in amyotrophic lateral sclerosis and its potential therapeutic modulation

Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder clinically characterized by muscle atrophy and progressive paralysis. Loss of motoneurons and pyramidal cells is thought to be the center piece of the complex and multifaceted ALS pathology, however, the exact mechani...

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Principais autores: Bernát Nógrádi, Dóra Nógrádi-Halmi, Barbara Erdélyi-Furka, Zalán Kádár, Tamás Csont, Renáta Gáspár
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2024-06-01
Series:Cell Death Discovery
Acceso en liña:https://doi.org/10.1038/s41420-024-02055-7
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