Chordoma cancer stem cell subpopulation characterization may guide targeted immunotherapy approaches to reduce disease recurrence

IntroductionCancer stem cells (CSCs), a group of tumor-initiating and tumor-maintaining cells, may be major players in the treatment resistance and recurrence distinctive of chordoma. Characterizing CSCs is crucial to better targeting this subpopulation.MethodsUsing flow cytometry, six chordoma cell...

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Autori principali:	Diana C. Lopez, Kellsye P. Fabian, Michelle R. Padget, Yvette L. Robbins, Joshua T. Kowalczyk, Wiem Lassoued, Danielle M. Pastor, Clint T. Allen, Gary L. Gallia, James L. Gulley, James W. Hodge, Nyall R. London
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2024-04-01
Serie:	Frontiers in Oncology
Soggetti:	chordoma cancer stem cells (CSC) tumor microenvironment (TME) immunotherapy PD-L1
Accesso online:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1376622/full
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