Assessment of Hsp90β-selective inhibitor safety and on-target effects
Abstract The heat shock protein 90 (Hsp90) family of molecular chaperones mediates the folding and activation of ~ 400 client proteins, many of which contribute to oncogenesis. As a result, Hsp90 pan-inhibitors, which inhibit all four Hsp90 isoforms, have been investigated in the clinic for the trea...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
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Nature Portfolio
2025-01-01
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| Schriftenreihe: | Scientific Reports |
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| Online-Zugang: | https://doi.org/10.1038/s41598-025-86647-y |
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