Membrane-Associated Ubiquitin Ligase RING Finger Protein 152 Orchestrates Melanogenesis via Tyrosinase Ubiquitination

Lysosomal degradation of tyrosinase, a pivotal enzyme in melanin synthesis, negatively impacts melanogenesis in melanocytes. Nevertheless, the precise molecular mechanisms by which lysosomes target tyrosinase have remained elusive. Here, we identify RING (Really Interesting New Gene) finger protein...

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Autori principali:	Ryota Ueda, Rina Hashimoto, Yuki Fujii, José C. J. M. D. S. Menezes, Hirotaka Takahashi, Hiroyuki Takeda, Tatsuya Sawasaki, Tomonori Motokawa, Kenzo Tokunaga, Hideaki Fujita
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2024-02-01
Serie:	Membranes
Soggetti:	lysosome melanogenesis melanosome RNF152 tyrosinase ubiquitin ligase
Accesso online:	https://www.mdpi.com/2077-0375/14/2/43
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