Expulsion of iron-rich ferritin via CD63-mediated exosome drives ferroptosis resistance in ovarian cancer cells

IntroductionFerroptosis is a promising new target for ovarian cancer (OVCA) treatment. However, some OVCA cell types resist the induction of ferroptosis by limiting the intracellular accumulation of the labile iron pool (LIP).MethodsHEY, COV318 and PEO4 were treated with erastin and assessed for cel...

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Autors principals:	Anna Martina Battaglia, Alessandro Sacco, Emanuele Giorgio, Lavinia Petriaggi, Julia Elzanowska, Ana Rita Cruz, Luis Rocha, Catarina Esteves Pereira, Maria Carolina Strano Moraes, Luca Palazzo, Claudia De Vitis, Bruno Costa-Silva, Flavia Biamonte
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-03-01
Col·lecció:	Frontiers in Cell and Developmental Biology
Matèries:	ovarian cancer ferroptosis resistance exosome ferritin iron
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1532097/full
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