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Overexpression of fatty acid synthase attenuates bleomycin induced lung fibrosis by restoring mitochondrial dysfunction in mice

Abstract Proper lipid metabolism is crucial to maintain alveolar epithelial cell (AEC) function, and excessive AEC death plays a role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The mRNA expression of fatty acid synthase (FASN), a key enzyme in the production of palmitate and other f...

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Príomhchruthaitheoirí: Hyesun Shin, Shinhee Park, Jisu Hong, Ae-Rin Baek, Junehyuk Lee, Do-Jin Kim, An-Soo Jang, Su Sie Chin, Sung Hwan Jeong, Sung-Woo Park
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Nature Portfolio 2023-06-01
Sraith:Scientific Reports
Rochtain ar líne:https://doi.org/10.1038/s41598-023-36009-3
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