Development of a Method for Producing Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor Using Fusion Protein Technology

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multifunctional cytokine with therapeutic applications in oncology and neurodegenerative diseases. However, its clinical use is limited by the high cost of eukaryotic production systems. Here, we developed a cost-effective <i>Escherichia...

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Principais autores:	Ekaterina A. Volosnikova, Tatiana I. Esina, Natalia V. Volkova, Svetlana V. Belenkaya, Yana S. Gogina, Galina G. Shimina, Elena A. Vyazovaya, Svetlana G. Gamaley, Elena D. Danilenko, Dmitriy N. Shcherbakov
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2025-08-01
Series:	Current Issues in Molecular Biology
Assuntos:	recombinant proteins rhGM-CSF SUMO fusion technology protein solubility enhancement therapeutic protein production protein chromatography
Acceso en liña:	https://www.mdpi.com/1467-3045/47/9/681
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