Seizure control via pH manipulation: a phase II double-blind randomised controlled trial of inhaled carbogen as adjunctive treatment of paediatric convulsive status epilepticus (Carbogen for Status Epilepticus in Children Trial (CRESCENT))

Abstract Background Paediatric convulsive status epilepticus is the most common neurological emergency presenting to emergency departments. Risks of resultant neurological morbidity and mortality increase with seizure duration. If the seizure fails to stop within defined time-windows, standard care...

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Detalhes bibliográficos

Principais autores:	Rob Forsyth, Maria Allen, Emma Bedson, Alice Downes, Chris Gough, Stuart Hartshorn, Kelly Lawton, Mark D. Lyttle, Shrouk Messahel, Niall Mullen, Joseph Raper, Anna Rosala-Harris, Leigh Taggart, Jason Urron, Emily Walton, Carrol Gamble, on behalf of the Paediatric Emergency Research in the United Kingdom and Ireland (PERUKI) collaborative
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-05-01
coleção:	Trials
Assuntos:	Convulsive status epilepticus Acid–base pH Respiratory acidosis Paediatrics Deferred consent
Acesso em linha:	https://doi.org/10.1186/s13063-024-08188-5
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