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Rapid and Efficient Gene Editing for Direct Transplantation of Naive Murine Cas9+ T Cells

Gene editing of primary T cells is a difficult task. However, it is important for research and especially for clinical T-cell transfers. CRISPR/Cas9 is the most powerful gene-editing technique. It has to be applied to cells by either retroviral transduction or electroporation of ribonucleoprotein co...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Snigdha Majumder, Isabelle Jugovic, Domenica Saul, Luisa Bell, Nadine Hundhausen, Rishav Seal, Andreas Beilhack, Andreas Rosenwald, Dimitrios Mougiakakos, Friederike Berberich-Siebelt
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021-07-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
CRISPR/Cas9
gRNA-only
GvHD
metabolism
NFAT
naive T-cell gene editing
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fimmu.2021.683631/full
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