Depletion of Tcf3 and Lef1 maintains mouse embryonic stem cell self-renewal
Mouse and rat embryonic stem cell (ESC) self-renewal can be maintained by dual inhibition of glycogen synthase kinase 3 (GSK3) and mitogen-activated protein kinase kinase (MEK). Inhibition of GSK3 promotes ESC self-renewal by abrogating T-cell factor 3 (TCF3)-mediated repression of the pluripotency...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Company of Biologists
2017-04-01
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| Schriftenreihe: | Biology Open |
| Schlagworte: | |
| Online-Zugang: | http://bio.biologists.org/content/6/4/511 |
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