IL7R remodels immunosuppression tumor microenvironment and promotes macrophage polarization by regulating NF-κB/CXCL1 axis in ovarian cancer

Abstract In the ovarian cancer microenvironment, the polarization of tumor-associated macrophages (TAMs) is closely associated with immunosuppressive phenotypes. Although elevated levels of circulating interleukin-7 (IL-7) have been linked to a poor prognosis, the regulatory mechanisms underlying th...

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Bibliografische Detailangaben

Hauptverfasser:	Yeqing Zheng, Cheng Qian, Shuyi Zhang, Meichen Wen, Xun Xu, Xuan Zhou, Yicong Wan, Lin Zhang, Wenjun Cheng
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2025-12-01
Schriftenreihe:	Cell Death and Disease
Online-Zugang:	https://doi.org/10.1038/s41419-025-08312-6
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