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In Silico Engineering of Synthetic Binding Proteins from Random Amino Acid Sequences

Summary: Synthetic proteins with high affinity and selectivity for a protein target can be used as research tools, biomarkers, and pharmacological agents, but few methods exist to design such proteins de novo. To this end, the In-Silico Protein Synthesizer (InSiPS) was developed to design synthetic...

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Hauptverfasser: Daniel Burnside, Andrew Schoenrock, Houman Moteshareie, Mohsen Hooshyar, Prabh Basra, Maryam Hajikarimlou, Kevin Dick, Brad Barnes, Tom Kazmirchuk, Matthew Jessulat, Sylvain Pitre, Bahram Samanfar, Mohan Babu, James R. Green, Alex Wong, Frank Dehne, Kyle K. Biggar, Ashkan Golshani
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019-01-01
Schriftenreihe:iScience
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2589004218302281
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