Verapamil Alleviates Myocardial Ischemia/Reperfusion Injury by Attenuating Oxidative Stress via Activation of SIRT1

Myocardial ischemia/reperfusion (I/R) injury is a potential complication of ischemic heart disease after recanalization. One of the primary reasons for I/R injury is the excessive accumulation of reactive oxygen species (ROS) in cardiomyocytes. Verapamil, a classic calcium channel blocker, has the p...

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Detalhes bibliográficos

Principais autores:	Mi Bao, Weiyi Huang, Yang Zhao, Xinzhe Fang, Yanmei Zhang, Fenfei Gao, Danmei Huang, Bin Wang, Ganggang Shi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-02-01
Colecção:	Frontiers in Pharmacology
Assuntos:	ischemia/reperfusion cardioprotection oxidative stress SIRT1 verapamil
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2022.822640/full
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