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Sex differences in progressive multiple sclerosis brain gene expression in oligodendrocytes and OPCs

Abstract Multiple sclerosis is a neurological autoimmune disease with sex-imbalanced incidence; in the USA, the disease is more likely to affect females at a ratio of 3:1. In addition, males are more likely to have a more severe disease course at time of diagnosis. Questions about both causes and do...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Brenna A. LaBarre, Devin King, Athanasios Ploumakis, Alfredo Morales Pinzon, Charles R.G. Guttmann, Nikolaos Patsopoulos, Tanuja Chitnis
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2025-12-01
Schriftenreihe:BMC Medical Genomics
Schlagworte:
Multiple sclerosis
Sex-specific
snRNA-seq
Oligodendrocytes
OPCs
Remyelination
Online-Zugang:https://doi.org/10.1186/s12920-025-02294-2
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