Outcome after Selective early treatment for Closure of patent ductus ARteriosus in preterm babies, a multicentre, masked, randomised placebo-controlled parallel group trial (Baby-OSCAR trial)

Background In extremely preterm babies, born before 28 weeks’ gestation, a large (≥ 1.5 mm in diameter) patent ductus arteriosus present beyond 3 days of age is associated with higher mortality and morbidity than infants without a patent ductus arteriosus. The cyclooxygenase inhibitor ibuprofen may...

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Autori principali:	Samir Gupta, Nimish V Subhedar, Jennifer L Bell, Ursula Bowler, Charlotte Clarke, Christina Cole, Kerrianne Dempster, Clare Edwards, David Field, Jane Greenaway, Elizabeth Hutchison, Nina Jamieson, Samantha Johnson, Wilf Kelsell, Ann Kennedy, Andy King, Marketa Laube, Louise Linsell, David Murray, Heather O’Connor, Chidubem Okeke Ogwulu, Justine Pepperell, Tracy Roberts, Charles Roehr, Sunil Sinha, Kayleigh Stanbury, Julia Sutton, Richard Welsh, Joy Wiles, Jonathan Wyllie, Edmund Juszczak, Pollyanna Hardy
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	NIHR Journals Library 2026-02-01
Serie:	Health Technology Assessment
Soggetti:	preterm patent ductus arteriosus ibuprofen bronchopulmonary dysplasia death infant child
Accesso online:	https://doi.org/10.3310/GJSG2422
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