Mechanistic insights into the selective oxidation of D-arginine by the nonheme iron-dependent viomycin biosynthesis enzyme VioC
Summary: VioC, a nonheme iron enzyme, catalyzes different reactions with D- and L-arginine, hydroxylating L-arginine at C3 and oxidatively deaminating D-arginine. Combining molecular dynamics with quantum mechanics/molecular mechanics (QM/MM) simulations, we reveal that the chirality of D-arginine p...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Elsevier
2025-12-01
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| Series: | iScience |
| Assuntos: | |
| Acceso en liña: | http://www.sciencedirect.com/science/article/pii/S2589004225024526 |
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